Principles of Drug Chemistry and Analysis

This module on Pharmaceutical Chemistry offers a thorough understanding of the chemical principles and techniques essential for the development and analysis of pharmaceutical compounds. It aims to provide a detailed insight into the fundamental and applied aspects of chemistry that are pivotal in drug discovery and development.

Key topics covered include:

• General Chemistry Principles:
  • Atomic structure and bonding: Students will explore the fundamental aspects of atomic theory, including the nature of chemical bonds and molecular interactions.
  • Acid-base chemistry: This section will cover the principles of acidity, basicity, pH, pKa, and their relevance in pharmaceutical contexts.
  • Organic chemistry fundamentals: An introduction to the structure, properties, and reactions of organic molecules, with a focus on those relevant to drug chemistry.
• Drug Chemistry:
  • Functional groups and drug design: Examination of various functional groups in drug molecules and their influence on drug design and activity.
  • Stereochemistry and drug activity: Understanding the role of stereochemistry in drug efficacy and how the spatial arrangement of atoms affects drug interactions.
  • Drug stability and degradation: Insights into the factors that influence drug stability, methods to prevent degradation, and the importance of maintaining drug integrity.
• Analytical Techniques:
  • Chromatography (HPLC, TLC): In-depth study of chromatographic techniques used for separating and analysing compounds, with an emphasis on high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC).
  • Spectroscopy (UV, IR): Coverage of spectroscopic methods used for structural elucidation and quantitative analysis, including ultraviolet (UV) and infrared (IR) spectroscopy.
  • Mass spectrometry: Detailed exploration of mass spectrometry, focusing on its applications in identifying and quantifying pharmaceutical compounds.

Through detailed notes, comprehensive flashcards, and targeted practice questions, students will not only gain a robust understanding of pharmaceutical chemistry but also develop practical skills essential for effective drug development and analysis. This module lays a solid foundation for further studies and careers in pharmaceutical sciences, ensuring students are well-prepared for the challenges of clinical practice and research.